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ea0094p67 | Metabolism, Obesity and Diabetes | SFEBES2023

The effect of snack foods containing rare sugars on glycaemic response, gut hormones and satiety in healthy UK adults

Smith Alison , Avery Amanda , Ford Rebecca , Goux Aurelie , Mukherjee Neil , Yang Qian , Jethwa Preeti

Dietary guidelines in the UK and worldwide recommend reducing the quantity of free sugars in the diet. The consumption of foods high in free sugars can lead to postprandial hyperglycaemia and hyperinsulinemia, which have been implicated in the development of metabolic diseases including type 2 diabetes and obesity. Rare sugars (naturally occurring monosaccharides which hardly exist in nature) have been found to suppress the postprandial elevation in blood glucose and improve g...

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ea0028p190 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2012

Investigating the sites and mechanisms by which peripheral prokineticin 2 administration reduces food intake and body weight in mice

Beale Kylie , Gardiner James , Bewick Gavin , Hostomska Klara , Patel Neekhil , Hussain Syed , Ebling Francis , Jethwa Preeti , Prosser Haydn , Ghatei Mohammad , Bloom Stephen , Dhillo Waljit

Prokineticin 2 (PK2) is a neuropeptide expressed in hypothalamic nuclei involved in the regulation of energy homeostasis, and has been shown to acutely reduce food intake in rodents. PK2 binds to and activates two G protein-coupled receptors, the PK receptor 1 (PKR1) and the PK receptor 2 (PKR2). We aimed to determine the sites and receptors which mediate the anorectic effects of peripherally administered PK2 within the CNS. We investigated neuronal activity in the hypothalamu...

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Endocrine Abstracts

The effect of snack foods containing rare sugars on glycaemic response, gut hormones and satiety in healthy UK adults

Investigating the sites and mechanisms by which peripheral prokineticin 2 administration reduces food intake and body weight in mice

BiosciAbstracts